Victor Lehot, Fanny Bousson, Lorenzo Turelli, Stéphane Erb, Isabelle Kuhn, Marc Nothisen, Sarah Cianférani, Guilhem Chaubet, Alain Wagner, Héloïse Cahuzac. “A dual screening strategy identifies delivery-dependent payload candidates for antibody-drug conjugates.” ChemRxiv (). https://doi.org/10.26434/chemrxiv.15007481/v1

The main paper refers to supporting information, but no separate supporting information file was found among the files available from the ChemRxiv record

Trastuzumab-fipronil and rituximab-fipronil antibody-drug conjugates
Native SEC-MS The intact D8 species in both spectra corresponded to a degree of conjugation of 8
Native SEC-MS, additional species a, b, and c Sequential in-source fragmentation of the carbamate moiety during MS ionization, corresponding to successive losses of 462 Da and consistent with the loss of one fipronil per fragmentation event
SEC No significant levels of high-molecular-weight aggregates