| Bicyclo[1.1.1]pentane derivative 50 | 2.26 |
|---|---|
| Bicyclo[1.1.1]pentane derivative 58 | 2.24 |
| Cyclopentane 48 | 2.23 |
| Gem-demethylated compound 47b | 3.58 |
| Gem-demethylated compound 58b | 3.78 |
| Bicyclo[2.1.1]hexane derivative 46a | 2.57 |
| Bicyclo[2.1.1]hexane derivative 54a | 2.44 |
| N-phenylbenzamide 53 | 2.58 |
| Cyclohexane analog 49 | 2.64 |
Andriy A. Koblik, Oleksandra V. Shvek, Bohdan V. Vashchenko, Dmytro S. Lesyk, Petro O. Borysko, Oleksandr V. Stryzhak, Oleksandr O. Grygorenko. “Bridgehead-functionalized bicyclo[2.1.1]hexanes – promising saturated isosteres of monosubstituted benzene.” ChemRxiv (). https://doi.org/10.26434/chemrxiv.15007511/v1
The main paper refers to supporting information, but no separate supporting information file was found among the files available from the ChemRxiv record
| Bicyclo[1.1.1]pentane amine derivative 63, pKa(H) | 8.60 |
|---|---|
| Bicyclo[1.1.1]pentane acid derivative 68, pKa | 4.10 |
| Bicyclo[2.1.1]hexane amine derivative 16a, pKa(H) | 9.65 |
| Bicyclo[2.1.1]hexane acid derivative 2a, pKa | 4.60 |
| Cyclohexylamine 62, pKa(H) | 10.50 |
| Cyclohexane reference 67, pKa | 4.87 |
| Bicyclo[2.2.1]heptane amine derivative 64, pKa(H) | 10.27 |
| Bicyclo[2.2.1]heptane acid derivative 69, pKa | 5.08 |
| Bicyclo[2.2.2]octane amine derivative 65, pKa(H) | 10.76 |
| Bicyclo[2.2.2]octane acid derivative 70, pKa | 5.42 |
| Gem-dimethyl bicyclo[2.1.1]hexane amine 16b, pKa(H) | 9.40 |
| Gem-dimethyl bicyclo[2.1.1]hexane acid 2b, pKa | 4.84 |
| Homologated bicyclo[2.1.1]hexane amines 3a and 3b, pKa(H) | 10.47–10.54 |
| Homologated bicyclo[2.1.1]hexane carboxylic acids 5a and 5b, pKa | 4.87–5.35 |