Compound characterization data — A. P. Clay et al., 2026

A. P. Clay, Thomas J. Polaske, Helen E. Blackwell. “A small molecule inhibitor of the Staphylococcus aureus agr quorum sensing system with low-nanomolar potency.” ChemRxiv (2026). https://doi.org/10.26434/chemrxiv.15007661/v1

Synthesized compounds
NMR purity, synthetic intermediates	≥ 90 %
NMR purity, final CP-20 derivatives	≥ 95 %, except for 18
NMR purity, Compound 18	89 %

Compound S1
Identifier	S1
¹H NMR (500 MHz, CD₃CN)	δ 8.30 (s, 1H), 7.65 (t, J = 2.0 Hz, 1H), 7.49 – 7.44 (m, 2H), 7.42 (ddd, J = 8.2, 2.1, 1.1 Hz, 1H), 7.35 (t, J = 8.1 Hz, 1H), 7.33 – 7.29 (m, 1H), 7.26 – 7.20 (m, 2H), 7.14 (ddd, J = 7.8, 2.0, 1.0 Hz, 1H) ppm
¹³C NMR (126 MHz, CD₃CN)	δ 152.56, 151.38, 140.51, 134.62, 131.01, 130.03, 126.32, 123.82, 122.48, 119.05 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 248.0473; measured 248.0473

Compound S2
Identifier	S2
¹H NMR (500 MHz, CDCl₃)	δ 7.54 (d, J = 2.2 Hz, 1H), 7.23 – 7.15 (m, 2H), 7.07 – 6.99 (m, 1H), 6.51 (s, 1H), 1.54 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 152.40, 139.58, 134.76, 129.91, 123.04, 118.52, 116.39, 81.02, 28.30 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 228.0786; measured 228.0782

Compound S3
Identifier	S3
¹H NMR (500 MHz, CDCl₃)	δ 9.59 (s, 1H), 4.57 (s, 2H), 3.83 – 3.64 (m, 2H), 2.80 (q, J = 8.0 Hz, 1H), 2.76 – 2.71 (m, 2H), 2.00 – 1.87 (m, 4H), 1.85 – 1.76 (m, 2H), 1.69 – 1.61 (m, 2H), 1.51 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 177.07, 173.83, 156.86, 154.68, 119.44, 80.36, 45.57, 41.80, 41.19, 30.23, 28.43, 26.46, 25.97 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 352.1689; measured 352.1683

Compound S4
Identifier	S4
¹H NMR (500 MHz, CDCl₃)	δ 9.61 (s, 1H), 4.58 (s, 2H), 3.75 (q, J = 6.1 Hz, 2H), 2.74 (t, J = 5.8 Hz, 2H), 2.64 (hept, J = 6.9 Hz, 1H), 1.50 (s, 9H), 1.29 (d, J = 6.9 Hz, 6H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 174.44, 171.17, 156.77, 154.68, 119.56, 80.48, 41.94, 35.49, 28.38, 26.54, 21.39, 19.18 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 326.1533; measured 326.1524

Compound S5
Identifier	S5
¹H NMR (500 MHz, CD₃CN)	δ 9.69 (s, 1H), 4.53 (t, J = 1.9 Hz, 2H), 3.70 (t, J = 5.8 Hz, 2H), 2.70 – 2.62 (m, 2H), 2.44 (t, J = 7.5 Hz, 2H), 1.72 – 1.62 (m, 2H), 1.47 (s, 9H), 1.45 – 1.35 (m, 2H), 0.95 (t, J = 7.4 Hz, 3H) ppm
¹³C NMR (126 MHz, CD₃CN)	δ 170.48, 156.36, 154.67, 143.06, 119.63, 80.35, 41.87, 40.95, 36.12, 28.43, 27.10, 26.62, 22.25, 13.71 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 340.1689; measured 340.1685

Compound S6
Identifier	S6
¹H NMR (500 MHz, CD₃CN)	δ 3.85 (t, J = 1.9 Hz, 2H), 3.04 (t, J = 5.8 Hz, 2H), 2.55 (tt, J = 5.7, 1.9 Hz, 2H), 2.40 (t, J = 7.5 Hz, 2H), 1.63 (p, J = 7.5 Hz, 2H), 1.36 (h, J = 7.4 Hz, 2H), 0.92 (t, J = 7.4 Hz, 3H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 171.49, 155.79, 143.16, 120.07, 43.19, 42.56, 35.08, 27.31, 27.04, 22.13, 14.10 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 240.1165; measured 240.1163

Compound S7
Identifier	S7
¹H NMR (500 MHz, CDCl₃)	δ 7.39 (s, 1H), 7.37 (s, 1H), 7.35 – 7.30 (m, 2H), 7.29 – 7.25 (m, 2H), 7.18 – 7.15 (m, 2H) 7.14 – 7.11 (m, 2H), 7.04 (t, J = 7.3 Hz, 1H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.56, 150.58, 137.37, 129.43, 129.20, 125.72, 123.97, 121.65, 118.74 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 214.0863; measured 214.0858

Compound S8
Identifier	S8
¹H NMR (500 MHz, CDCl₃)	δ 8.10 (d, J = 8.3 Hz, 1H), 7.81 (d, J = 8.3 Hz, 1H), 7.41 (t, J = 7.7 Hz, 2H), 7.36 (t, J = 7.8 Hz, 1H), 7.30 (s, 1H), 7.27 – 7.24 (m, 1H), 7.23 (d, J = 8.0 Hz, 2H), 6.84 (t, J =7.9 Hz, 1H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.59, 150.48, 139.01, 137.97, 129.58, 129.47, 129.45, 125.88, 125.58, 121.63, 120.42 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 339.9829; measured 339.9826

Compound S9
Identifier	S9
¹H NMR (500 MHz, CDCl₃)	δ 7.64 (d, J = 8.4 Hz, 2H), 7.40 (t, J = 7.7 Hz, 2H), 7.26 – 7.22 (m, 3H), 7.18 (d, J = 4.0, 2H), 6.89 (s, 1H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.36, 150.42, 138.11, 137.23, 129.48, 125.89, 121.57, 120.60, 86.97 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 339.9829; measured 339.9824

Compound S10
Identifier	S10
¹H NMR (500 MHz, CDCl₃)	δ 7.52 (s, 1H), 7.39 (t, J = 7.9 Hz, 2H), 7.28 – 7.21 (m, 3H), 7.19 (d, J = 8.1 Hz, 2H), 7.14 (d, J = 7.4, 1H), 6.91 (s, 1H), 1.32 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 152.54, 151.72, 150.62, 137.10, 129.43, 128.79, 125.70, 121.71, 121.06, 116.00, 115.28, 34.82, 31.28 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 270.1489; measured 270.1486

Compound S11
Identifier	S11
¹H NMR (500 MHz, DMSO-d₆)	δ 7.25 (s, 1H), 7.15 (t, J = 7.7 Hz, 1H), 7.12 – 7.05 (m, 1H), 6.84 (d, J = 7.4 Hz, 1H), 6.49 (s, 1H), 2.31 (s, 3H), 1.51 (s, 9H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 152.83, 138.89, 138.30, 128.76, 123.82, 119.17, 115.62, 80.38, 28.36, 21.50 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 208.1332; measured 208.1330

Compound S12
Identifier	S12
¹H NMR (500 MHz, CDCl₃)	δ 8.18 (d, J = 8.3 Hz, 1H), 7.63 (d, J = 7.9 Hz, 1H), 7.57 (t, J = 7.9 Hz, 1H), 7.41 (t, J = 7.7 Hz, 2H), 7.27 – 7.19 (m, 5H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.61, 150.42, 135.20, 133.12, 129.48, 126.21, 125.95, 125.17, 124.03, 123.00, 121.56 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 282.0736; measured 272.0731

Compound S13
Identifier	S13
¹H NMR (500 MHz, CDCl₃)	δ 7.61 (s, 1H), 7.42 – 7.36 (m, 2H), 7.24 (t, J = 7.1 Hz, 2H), 7.21 – 7.14 (m, 3H), 7.04 (dd, J = 8.2, 2.1 Hz, 1H), 6.91 (s, 1H), 6.48 (s, 1H), 1.51 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 152.60, 151.46, 150.56, 139.23, 138.11, 129.71, 129.40, 125.70, 121.65, 113.80, 113.21, 108.71, 80.76, 28.33 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 346.1761; measured 346.1760

Compound S14
Identifier	S14
¹H NMR (500 MHz, CD₃CN)	δ 7.45 – 7.35 (m, 4H), 7.35 – 7.30 (m, 2H), 7.28 – 7.22 (m, 1H), 7.18 – 7.12 (m, 2H), 6.51 (s, 1H), 4.38 (d, J = 6.3 Hz, 2H) ppm
¹³C NMR (126 MHz, CD₃CN)	δ 155.60, 151.96, 142.26, 134.37, 130.77, 129.88, 127.79, 127.76, 126.34, 125.86, 122.38, 44.42 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 262.0629; measured 262.0624

Compound S15
Identifier	S15
¹H NMR (500 MHz, CDCl₃)	δ 7.17 (t, J = 8.1 Hz, 1H), 7.10 (s, 1H), 6.86 – 6.80 (dd, J = 7.8, 1.3 Hz, 1H), 6.58 (ddd, J = 8.3, 2.5, 0.9 Hz, 1H), 6.46 (s, 1H), 3.80 (s, 3H), 1.52 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 160.30, 152.61, 139.65, 129.65, 110.69, 108.91, 104.12, 80.54, 55.28, 28.35 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 224.1281; measured 224.1278

Compound S16
Identifier	S16
¹H NMR (500 MHz, CDCl₃)	δ 7.26 (d, J = 8.7 Hz, 2H), 6.86 – 6.80 (m, 2H), 6.33 (s, 1H), 3.78 (s, 3H), 1.51 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 155.73, 153.16, 131.44, 120.58, 114.22, 80.24, 55.53, 28.39 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 224.1281; measured 224.1278

Compound S17
Identifier	S17
¹H NMR (500 MHz, CDCl₃)	δ 7.37 (t, J = 7.7 Hz, 2H), 7.20 (t, J = 7.4 Hz, 1H), 7.15 (d, J = 7.7 Hz, 2H), 4.91 (s, 1H), 3.66 – 3.53 (m, 1H), 2.04 (d, J = 12.4 Hz, 2H), 1.77 (dt, J = 12.9, 3.9 Hz, 2H), 1.65 (dt, J = 12.9, 3.9 Hz, 1H), 1.47 – 1.34 (m, 2H), 1.29 – 1.19 (m, 3H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 153.66, 151.13, 129.24, 125.12, 121.60, 50.12, 33.29, 25.48 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 220.1332; measured 220.1332

Compound S18
Identifier	S18
¹H NMR (500 MHz, CDCl₃)	δ 7.35 (t, J = 7.9 Hz, 2H), 7.18 (t, J = 7.4 Hz, 1H), 7.12 (d, J = 7.9 Hz, 2H), 4.97 (s, 1H), 3.27 (q, J = 6.8 Hz, 2H), 1.58 (q, J = 7.1 Hz, 2H), 1.41 – 1.23 (m, 6H), 0.95 – 0.84 (m, 3H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 154.57, 151.12, 129.26, 125.19, 121.60, 41.30, 31.46, 29.82, 26.43, 22.57, 14.01 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 222.1489; measured 222.1488

Compound S19
Identifier	S19
¹H NMR (500 MHz, CDCl₃)	δ 7.37 (t, J = 7.8 Hz, 2H), 7.20 (t, J = 7.4 Hz, 1H), 7.14 (d, J = 7.8 Hz, 2H), 1.42 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 152.78, 150.97, 129.22, 125.09, 121.75, 50.86, 28.83 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 194.1176; measured 194.1176

Compound S20
Identifier	S20
¹H NMR (500 MHz, CD₃CN)	δ 8.41 (s, 1H), 8.11 (s, 1H), 7.90 (d, J = 8.9 Hz, 1H), 7.86 (t, J = 8.9 Hz, 2H), 7.60 (dd, J = 7.3, 2.1 Hz, 1H), 7.54 – 7.43 (m, 4H), 7.32 (td, J = 7.3, 1.1 Hz, 1H), 7.28 – 7.23 (m, 2H) ppm
¹³C NMR (126 MHz, CD₃CN)	δ 152.82, 151.57, 136.65, 134.46, 130.82, 130.02, 129.35, 128.14, 127.87, 127.20, 126.22, 125.42, 122.56, 120.07, 115.47 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 264.1019; measured 264.1014

Compound S21
Identifier	S21
¹H NMR (500 MHz, CD₃CN)	δ 8.21 (s, 1H), 8.17 (d, J = 8.2 Hz, 1H), 7.98 (dd, J = 8.0, 1.5 Hz, 1H), 7.83 (d, J = 8.2 Hz, 1H), 7.77 (d, J = 7.5 Hz, 1H), 7.66 – 7.57 (m, 2H), 7.56 (t, J = 7.9 Hz, 1H), 7.49 – 7.44 (m, 2H), 7.33 – 7.25 (m, 3H) ppm
¹³C NMR (126 MHz, CD₃CN)	δ 154.05, 151.82, 134.77, 133.46, 130.31, 130.01, 128.92, 127.09, 126.89, 126.56, 126.24, 126.15, 122.69, 122.53, 121.80 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 264.1019; measured 264.1013

Compound S22
Identifier	S22
¹H NMR (500 MHz, CDCl₃)	δ 7.44 – 7.38 (m, 4H), 7.28 – 7.25 (m, 1H), 7.20 – 7.16 (m, 2H), 7.11 (t, J = 1.8 Hz, 1H), 6.93 (s, 1H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.18, 150.24, 139.28, 135.53, 129.53, 126.08, 123.97, 121.49, 117.05 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 282.0083; measured 282.0082

Compound S23
Identifier	S23
¹H NMR (500 MHz, CDCl₃)	δ 7.44 – 7.40 (m, 2H), 7.34 (s, 2H), 7.28 – 7.24 (m, 1H), 7.24 – 7.19 (m, 3H), 6.91 (s, 1H), 1.35 (s, 18H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 151.91, 151.84, 150.65, 136.70, 129.43, 125.67, 121.76, 118.13, 113.42, 34.98, 31.39 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 326.2115; measured 326.2112

Compound S24
Identifier	S24
¹H NMR (500 MHz, CDCl₃)	δ 7.11 – 6.98 (m, 3H), 5.92 (s, 1H), 2.25 (s, 6H), 1.53 – 1.30 (br s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 153.68, 135.79, 134.01, 128.08, 126.84, 79.78, 28.32, 18.34 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 222.1489; measured 222.1486

Compound S25
Identifier	S25
¹H NMR (500 MHz, CDCl₃)	δ 7.97 (dd, J = 3.0, 1.3 Hz, 1H), 7.62 (s, 1H), 7.50 – 7.38 (m, 3H), 7.08 (d, J = 8.2 Hz, 1H), 4.55 (s, 2H), 3.64 (t, J = 5.9 Hz, 2H), 2.84 (t, J = 6.0 Hz, 2H), 1.50 (s, 9H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 161.43, 155.08, 137.90, 136.24, 135.63, 130.05, 128.88, 126.89, 126.76, 126.47, 120.69, 118.73, 80.01, 45.09, 41.93, 29.21, 28.62 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 376.1689; measured 376.1686

Compound S26
Identifier	S26
¹H NMR (500 MHz, CDCl₃)	δ 7.96 (dd, J = 3.0, 1.4 Hz, 1H), 7.57 (s, 1H), 7.48 (dd, J = 5.1, 1.4 Hz, 1H), 7.44 (d, J = 2.1 Hz, 1H), 7.40 (dd, J = 4.9, 2.9 Hz, 1H), 7.30 (dd, J = 8.2, 2.3 Hz, 1H), 7.00 (d, J = 8.2 Hz, 1H), 4.01 (s, 2H), 3.15 (t, J = 5.9 Hz, 2H), 2.82 (t, J = 6.0 Hz, 2H) ppm
¹³C NMR (126 MHz, CDCl₃)	δ 161.03, 137.92, 135.72, 135.61, 132.05, 128.54, 126.91, 126.86, 126.04, 120.90, 118.04, 47.88, 43.71, 29.25 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 259.0900; measured 259.0900

Compound 5
Identifier	5
¹H NMR (500 MHz, DMSO-d₆)	δ 11.97 (s, 1H), 8.84 (s, 1H), 7.65 (t, J = 2.1 Hz, 1H), 7.42 (ddd, J = 8.4, 2.1, 1.0 Hz, 1H), 7.26 (t, J = 8.1 Hz, 1H), 6.99 (ddd, J = 7.9, 2.1, 0.9 Hz, 1H), 4.62 (t, J = 1.9 Hz, 2H), 3.79 (t, J = 5.8 Hz, 2H), 2.89 (p, J = 7.9 Hz, 1H), 2.70 (t, J = 5.8 Hz, 2H), 1.92 – 1.80 (m, 2H), 1.76 – 1.61 (m, 4H), 1.61 – 1.51 (m, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 174.67, 156.62, 155.12, 143.42, 142.50, 133.20, 130.44, 121.91, 119.43, 118.76, 118.32, 44.37, 42.17, 30.34, 26.80, 26.14 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 405.1147; measured 405.1149

Compound 6
Identifier	6
¹H NMR (500 MHz, DMSO-d₆)	δ 11.95 (s, 1H), 8.84 (s, 1H), 7.65 (t, J = 2.1 Hz, 1H), 7.42 (ddd, J = 8.4, 2.1, 0.9 Hz, 1H), 7.26 (t, J = 8.1 Hz, 1H), 6.99 (ddd, J = 7.8, 2.1, 0.9 Hz, 1H), 4.62 (d, J = 1.8 Hz, 2H), 3.79 (t, J = 5.8 Hz, 2H), 2.70 (td, J = 6.6, 3.0 Hz, 3H), 1.10 (d, J = 6.8 Hz, 6H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 175.49, 156.59, 155.12, 143.43, 142.49, 133.20, 130.44, 121.92, 119.43, 118.81, 118.33, 42.18, 42.14, 34.24, 26.80, 19.57 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 379.099; measured 379.0992

Compound 7
Identifier	7
¹H NMR (500 MHz, DMSO-d₆)	δ 11.97 (s, 1H), 8.85 (s, 1H), 7.66 (s, 1H), 7.42 (d, J = 8.1 Hz, 1H), 7.27 (t, J = 8.1 Hz, 1H), 7.00 (d, J = 8.1Hz, 1H), 4.63 (s, 2H), 3.79 (t, J = 5.8 Hz, 2H), 2.71 (t, J = 5.8 Hz, 2H), 2.41 (t, J = 7.4 Hz, 2H), 1.58 (p, J = 7.5 Hz, 2H), 1.34 – 1.26 (m, 2H), 0.89 (t, J = 7.4 Hz, 3H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 171.65, 156.45, 155.12, 143.41, 142.50, 133.20, 130.44, 121.92, 119.43, 118.75, 118.33, 42.18, 42.14, 35.07, 27.28, 26.81, 22.13, 14.11 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 393.1147; measured 393.1148

Compound 8
Identifier	8
¹H NMR (500 MHz, DMSO-d₆)	δ 12.43 (s, 1H), 8.67 (s, 1H), 8.58 (dd, J = 3.0, 1.3 Hz, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.50 – 7.45 (m, 2H), 7.27 – 7.21 (m, 2H), 6.95 (dd, J = 7.3, 1.2 Hz, 1H), 4.67 (s, 2H), 3.82 (t, J = 5.7 Hz, 2H), 2.76 (td, J = 5.5, 2.8 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.48, 155.50, 143.80, 140.83, 135.57, 132.06, 129.83, 128.79, 127.94, 127.64, 122.41, 120.32, 115.69, 42.16, 40.61, 26.79 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 385.0787; measured 385.0788

Compound 12
Identifier	12
¹H NMR (500 MHz, DMSO-d₆)	δ 12.42 (s, 1H), 8.58 (dd, J = 3.0, 1.3 Hz, 1H), 8.39 (s, 1H), 7.84 (dd, J = 7.9, 1.4 Hz, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.43 – 7.32 (m, 2H), 6.94 (ddd, J = 8.0, 7.0, 2.0 Hz, 1H), 4.68 (d, J = 2.0 Hz, 2H), 3.84 (t, J = 5.7 Hz, 2H), 2.81 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	155.57, 143.82, 141.37, 139.07, 135.57, 132.06, 129.83, 129.04, 128.24, 127.94, 127.64, 127.47, 119.26, 115.69, 99.06, 42.31, 42.10, 26.87 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 510.9754; measured 510.9757

Compound 13
Identifier	13
¹H NMR (500 MHz, DMSO-d₆)	12.44 (s, 1H), 8.78 (s, 1H), 8.58 (s, 1H), 7.73 (d, J = 4.87 Hz, 1H), 7.68 (d, J = 4.87 Hz, 1H), 7.57 (d, J = 8.77 Hz, 2H), 7.34 (d, J = 8.77 Hz, 2H), 4.66 (s, 2H), 3.81 (t, d = 5.69 Hz, 2H), 2.45 (t, J = 5.79 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 168.93, 155.19, 140.85, 139.62, 137.77, 137.40, 132.08, 127.94, 127.64, 122.44, 121.63, 119.48, 85.42, 42.15, 26.77, 24.52 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 510.9754; measured 510.9758

CP-20t
Identifier	14
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.60 (s, 1H), 8.58 (d, J = 1.6 Hz, 1H), 7.73 (dd, J = 5.1, 1.4 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.47 (t, J = 2.0 Hz, 1H), 7.35 (ddd, J = 8.1, 2.1, 1.0 Hz, 1H), 7.16 (t, J = 7.9 Hz, 1H), 6.98 (ddd, J = 7.8, 1.9, 1.0 Hz, 1H), 4.67 (s, 1H), 3.82 (t, J = 5.7 Hz, 2H), 2.76 (J = 5.7 Hz, 2H), 1.26 (s, 9H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.38, 155.69, 154.45, 150.18, 142.72, 139.43, 134.49, 130.99, 128.75, 127.30, 126.86, 126.56, 118.28, 116.57, 116.32, 41.05, 39.44, 33.77, 30.57, 25.73 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 441.1413; measured 441.1415

Compound 15
Identifier	15
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.70 – 8.51 (m, 2H), 7.73 (dd, J = 5.0, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.30 (d, J = 2.0 Hz, 1H), 7.29 – 7.24 (m, 1H), 7.12 (t, J = 7.8 Hz, 1H), 6.77 (dd, J = 7.5, 1.7, 0.9 Hz, 1H), 4.66 (s, 2H), 3.81 (t, J = 5.8 Hz, 2H), 2.75 (t, J = 5.8 Hz, 2H), 2.25 (s, 3H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.96, 156.20, 154.99, 143.32, 140.23, 137.33, 135.05, 131.56, 128.14, 127.43, 127.14, 122.62, 120.40, 119.16, 116.95, 41.66, 40.11, 26.27, 21.16 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 399.0944; measured 399.0946

Compound 16
Identifier	16
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.59 (s, 1H), 8.44 (s, 1H), 7.77 – 7.68 (m, 3H), 7.66 (d, J = 7.6 Hz, 1H), 7.47 – 7.39 (m, 2H), 4.66 (s, 2H), 3.82 (t, J = 5.8 Hz, 2H), 2.76 (t, J = 5.8 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO)	δ 159.98, 156.25, 155.88, 143.24, 137.23,135.09, 132.70, 131.56, 130.79, 127.44,127.15,126.15, 125.90, 125.67, 122.72, 119.12, 41.81, 41.55, 26.11 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 453.0661; measured 453.0663

Compound 17
Identifier	17
¹H NMR (500 MHz, DMSO-d₆)	δ 12.42 (s, 1H), 8.56 (s, 1H), 8.38 (s, 1H), 7.72 (dd, J = 5.1, 1.3 Hz, 1H), 7.67 (dd, J = 5.1, 2.9 Hz, 1H), 6.85 (t, J = 8.0 Hz, 1H), 6.77 (t, J = 2.1 Hz, 1H), 6.59 (dt, J = 8.0, 1.4 Hz, 1H), 6.18 (ddd, J = 7.9, 2.3, 1.0 Hz, 1H), 4.91 (s, 2H), 4.63 (t, J = 1.9 Hz, 2H), 3.78 (t, J = 5.8 Hz, 2H), 2.73 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.82, 157.46, 155.56, 149.17, 143.58, 141.33, 136.16, 131.76, 128.98, 127.71, 127.70, 119.77, 108.77, 108.53, 106.35, 42.24, 40.61, 26.79 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 400.0896; measured 400.0899

Compound 18
Identifier	18
¹H NMR (500 MHz, DMSO-d₆)	δ 12.39 (s, 1H), 8.57 (d, J = 2.7 Hz, 1H), 7.78 – 7.71 (m, 1H), 7.69 (dd, J = 5.1, 2.9 Hz, 1H), 7.38 – 7.20 (m, 5H), 4.57 (s, 2H), 4.27 (d, J = 5.8 Hz, 2H), 3.72 (t, J = 5.7 Hz, 2H), 2.69 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.53, 157.76, 144.07, 135.65, 133.31, 132.01, 130.50, 129.83, 127.91, 127.64, 127.32, 126.89, 126.21, 119.79, 115.70, 43.60, 41.82, 40.60, 26.60 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 433.0554; measured 433.0557

Compound 19
Identifier	19
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.67 (s, 1H), 8.59 (d, J = 2.9 Hz, 1H), 7.76 – 7.65 (m, 2H), 7.19 – 7.04 (m, 3H), 6.53 (dd, J = 8.0, 2.5 Hz, 1H), 4.66 (s, 2H), 3.82 (t, J = 5.7 Hz, 2H), 3.71 (s, 3H), 2.75 (t, J = 5.8 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.84, 155.35, 142.10, 135.54, 132.07, 129.50, 129.37, 128.68, 127.94, 127.64, 125.79, 118.11, 112.45, 107.92, 105.86, 55.36, 44.48, 42.16, 26.78 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 415.0893; measured 415.0895

Compound 20
Identifier	20
¹H NMR (500 MHz, DMSO-d₆)	δ 12.43 (s, 1H), 8.56 (s, 1H), 8.51 (s, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.38 – 7.32 (m, 2H), 6.86 – 6.80 (m, 2H), 4.64 (s, 2H), 3.80 (t, J = 5.7 Hz, 2H), 3.70 (s, 3H), 2.74 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.63, 157.06, 155.73, 155.11, 143.72, 135.80, 133.75, 131.95, 127.87, 127.66, 122.32,119.59, 114.01, 55.60, 42.09, 42.06, 26.77 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 415.0893; measured 415.0894

Compound 21
Identifier	21
¹H NMR (500 MHz, DMSO-d₆)	δ 12.41 (s, 1H), 8.58 (s, 1H), 7.73 (dd, J = 5.0, 1.4 Hz, 1H), 7.69 (dd, J = 5.1, 2.9 Hz, 1H), 6.33 (d, J = 7.7 Hz, 1H), 4.50 (t, J = 1.8 Hz, 2H), 3.67 (t, J = 5.7 Hz, 2H), 3.47 –3.39 (m 1H), 2.65 (t, J = 5.7 Hz, 2H), 1.82 – 1.63 (m, 4H), 1.63 – 1.52 (m, 1H), 1.34 – 1.01 (m, 5H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.41, 157.07, 156.54, 143.83, 135.58, 132.02, 127.92, 127.63, 119.98, 49.77, 41.74, 41.66, 33.60, 26.62, 25.86, 25.56 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 391.1257; measured 391.1258

Compound 22
Identifier	22
¹H NMR (500 MHz, DMSO-d₆)	δ 12.40 (s, 1H), 8.57 (dd, J = 2.9, 1.4 Hz, 1H), 7.72 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.0, 2.9 Hz, 1H), 6.63 (t, J = 5.5 Hz, 1H), 4.49 (d, J = 1.9 Hz, 2H), 3.65 (t, J = 5.7 Hz, 2H), 3.03 (td, J = 7.2, 5.6 Hz, 2H), 2.65 (d, J = 5.4 Hz, 2H), 1.40 (t, J = 7.1 Hz, 2H), 1.30 – 1.20 (m, 6H), 0.88 – 0.82 (m, 3H)
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.42, 157.76, 156.55, 143.81, 135.58, 132.02, 127.92, 127.63, 119.99, 115.69, 41.73, 40.71, 40.61, 31.55, 30.21, 26.55, 22.54, 14.38
MS (ESI-EMM)	[M+H]⁺ calculated 393.1413; measured 393.1413

Compound 23
Identifier	23
¹H NMR (500 MHz, DMSO-d₆)	δ 12.40 (s, 1H), 8.57 (s, 1H), 7.73 (dd, J = 5.1, 0.85 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1Hf), 5.94 (s, 1H), 4.47 (s, 2H), 3.63 (t, J = 5.7 Hz, 2H), 2.65 (s, 2H), 1.27 (s, 9H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.93, 156.68, 156.05, 143.36, 135.11, 131.51, 127.42, 127.14, 119.48, 54.88, 50.07, 41.32, 29.17, 26.21 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 365.1100; measured 365.1102

Compound 24
Identifier	24
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.91 (s, 1H), 8.58 (s, 1H), 8.03 (s, 1H), 7.81 (s, 2H), 7.79 (s, 1H), 7.74 (t, J = 7.4 Hz, 2H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.64 (dd, J = 8.9, 2.2 Hz, 1H), 7.43 (t, J = 7.5 Hz, 1H), 7.35 (t, J = 7.5 Hz, 1H), 4.72 (s, 2H), 3.87 (t, J = 5.8 Hz, 2H), 2.80 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.02, 156.31, 155.08, 143.30, 138.08, 135.09, 133.49, 131.58, 129.17, 127.75, 127.45, 127.34, 127.15, 126.93, 126.11, 123.96, 121.12, 119.12, 115.17, 41.73, 40.11, 26.31 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 435.0944; measured 435.0946

Compound 25
Identifier	25
¹H NMR (500 MHz, DMSO-d₆)	δ 12.45 (s, 1H), 8.80 (s, 1H), 8.59 (s, 1H), 7.97 – 7.89 (m, 2H), 7.77 – 7.72 (m, 2H), 7.69 (dd, J = 5.0, 2.9 Hz, 1H), 7.54 – 7.41 (m, 4H), 4.75 (s, 2H), 3.92 (t, J = 5.7 Hz, 2H), 2.83 (t, J = 5.7 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.98, 156.17, 143.36, 135.32, 135.09, 133.74, 131.58, 129.51, 127.89, 127.45, 127.16, 125.77, 125.50, 125.06, 123.46, 123.09, 119.30, 41.85, 41.74, 26.38 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 435.0944; measured 435.0947

Compound 26
Identifier	26
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 9.01 (s, 1H), 8.58 (d, J = 2.9 Hz, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.62 (d, J = 1.9 Hz, 2H), 7.14 (s, 1H), 4.68 (s, 2H), 3.82 (t, J = 5.7 Hz, 2H), 2.76 (t, J = 5.6 Hz, 2H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.04, 156.40, 154.30, 143.20, 143.02, 135.07, 133.68, 131.61, 127.46, 127.15, 120.79, 118.78, 117.33, 41.68, 40.11, 26.23 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 453.0008; measured 453.0008

Compound 27
Identifier	27
¹H NMR (500 MHz, DMSO-d₆)	δ 12.44 (s, 1H), 8.58 (t, J = 2.1 Hz, 1H), 8.53 (s, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.35 (d, J = 1.7 Hz, 2H), 7.00 (t, J = 1.8 Hz, 1H), 4.66 (s, 2H), 3.82 (t, J = 5.7 Hz, 2H), 2.76 (s, 2H), 1.26 (s, 18H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 159.96, 156.24, 155.09, 150.11, 143.32, 139.61, 135.08, 131.56, 127.43, 127.14, 119.20, 115.66, 114.43, 54.88, 41.60, 34.49, 31.27, 26.31 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 497.204; measured 497.204

Compound 28
Identifier	28
¹H NMR (500 MHz, DMSO-d₆)	δ 12.42 (s, 1H), 8.58 (s, 1H), 8.07 (s, 1H), 7.73 (dd, J = 5.1, 1.3 Hz, 1H), 7.68 (dd, J = 5.1, 2.9 Hz, 1H), 7.06 – 7.03 (m, 3H), 4.66 (s, 2H), 3.82 (t, J = 5.7 Hz, 2H), 2.76 (t, J = 5.7 Hz, 2H), 2.12 (s, 6H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 172.46, 156.03, 136.85, 136.37, 135.63, 133.84, 132.04, 128.03, 127.93, 127.64, 126.35, 120.21, 42.35, 26.69, 21.53, 18.53 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 413.11; measured 413.1106

Compound 29
Identifier	29
¹H NMR (500 MHz, DMSO-d₆)	δ 9.99 (s, 1H), 8.75 (s, 1H), 8.33 (dd, J = 2.8, 1.4 Hz, 1H), 7.68 (t, J = 2.1 Hz, 1H), 7.66 – 7.60 (m, 3H), 7.55 (dd, J = 8.3, 2.2 Hz, 1H), 7.46 – 7.42 (m, 1H), 7.26 (t, J = 8.1 Hz, 1H), 7.15 (d, J = 8.3 Hz, 1H), 6.98 (ddd, J = 8.0, 2.1, 0.9 Hz, 1H), 4.61 (s, 2H), 3.70 (t, J = 5.9 Hz, 2H), 2.85 (t, J = 5.9 Hz, 2H)
¹³C NMR (126 MHz, DMSO-d₆)	δ 161.24, 155.11, 142.68, 138.30, 137.74, 135.37, 133.18, 130.40, 130.04, 129.43, 127.65, 127.37, 126.87, 121.74, 120.62, 119.37, 118.92, 118.27, 45.80, 41.86, 29.01
MS (ESI-EMM)	[M+H]⁺ calculated 412.0881; measured 412.0881

Compound 30
Identifier	30
¹H NMR (500 MHz, DMSO-d₆)	δ 9.98 (s, 1H), 8.48 (s, 1H), 8.33 (dd, J = 2.8, 1.4 Hz, 1H), 7.68 – 7.60 (m, 3H), 7.55 (dd, J = 8.3, 2.2 Hz, 1H), 7.48 (t, J = 2.0 Hz, 1H), 7.36 (ddd, J = 8.1, 2.2, 1.0 Hz, 1H), 7.15 (dt, J = 7.9, 3.8 Hz, 2H), 6.97 (ddd, J = 7.8, 1.9, 1.0 Hz, 1H), 4.61 (s, 2H), 3.70 (t, J = 5.9 Hz, 2H), 2.85 (t, J = 5.9 Hz, 2H), 1.26 (s, 9H) ppm
¹³C NMR (126 MHz, DMSO-d₆)	δ 160.15, 154.46, 150.13, 139.60, 137.23, 136.60, 134.36, 128.94, 128.60, 127.26, 126.56, 126.28, 125.79, 119.56, 118.09, 117.81, 116.52, 116.29, 44.75, 40.73, 33.77, 30.58, 28.00 ppm
MS (ESI-EMM)	[M+H]⁺ calculated 434.1897; measured 434.1899