Magdalena Gaca-Tabaszewska, Joanna Bogusiewicz, Mateusz Wiebskowski, Jacek Furtak, Marek Harat, Barbara Bojko. “Quantitative SPME-LC-MS profiling reveals metabolite signatures associated with molecular alterations in human gliomas.” ChemRxiv (). https://doi.org/10.26434/chemrxiv.15007889/v1

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Human glioma tumors
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, IDH mutation 0 α-Aminoadipic acid: 19.05 / 65.87; phenylalanine: 28.48 / 14.75; cystathionine: 80.82 / 205.63; acetylcarnitine: 31.22 / 25.92; propionylcarnitine: 1.68 / 1.91
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, IDH mutation 1 α-Aminoadipic acid: 5.25 / 17.52; phenylalanine: 23.08 / 22.55; cystathionine: 201.53 / 153.29; acetylcarnitine: 16.04 / 11.8; propionylcarnitine: 1.05 / 3.06
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, MGMT methylation 0 α-Aminoadipic acid: 24.72 / 68.63; phenylalanine: 30.22 / 10.35; cystathionine: 89.08 / 176.14; acetylcarnitine: 33.96 / 22.87; propionylcarnitine: 1.68 / 2.7
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, MGMT methylation 1 α-Aminoadipic acid: 11.25 / 22.92; phenylalanine: 25.56 / 17.88; cystathionine: 124.79 / 242.9; acetylcarnitine: 24.92 / 32.91; propionylcarnitine: 1.6 / 1.87
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, EGFR amplification 0 α-Aminoadipic acid: 9.38 / 15.4; phenylalanine: 17.65 / 19.03; cystathionine: 102.83 / 184.49; acetylcarnitine: 19.22 / 16.34; propionylcarnitine: 1.56 / 3.74
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, EGFR amplification 1 α-Aminoadipic acid: 24.72 / 112; phenylalanine: 30.22 / 8.07; cystathionine: 97.35 / 257.3; acetylcarnitine: 37.65 / 36.64; propionylcarnitine: 1.68 / 1.81
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, CDKN2A/2B deletion 0 α-Aminoadipic acid: 18.52 / 23.86; phenylalanine: 23.93 / 24.74; cystathionine: 161.42 / 116.93; acetylcarnitine: 27.83 / 28.96; propionylcarnitine: 3.21 / 4.32
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, CDKN2A/2B deletion 1 α-Aminoadipic acid: 19.92 / 56.96; phenylalanine: 29.11 / 12.67; cystathionine: 87.29 / 288.91; acetylcarnitine: 25.42 / 31.54; propionylcarnitine: 1.44 / 1.38
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, PTEN deletion 0 α-Aminoadipic acid: 5.25 / 14.25; phenylalanine: 16.52 / 21.07; cystathionine: 161.42 / 180.76; acetylcarnitine: 16.04 / 30.16; propionylcarnitine: 1.91 / 3.52
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, PTEN deletion 1 α-Aminoadipic acid: 25.67 / 102.08; phenylalanine: 30.13 / 9; cystathionine: 59.17 / 177.81; acetylcarnitine: 25.64 / 23.96; propionylcarnitine: 1.18 / 0.8
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, TERT alteration 0 α-Aminoadipic acid: 18.52 / 20.26; phenylalanine: 23.65 / 16.19; cystathionine: 124.76 / 105.4; acetylcarnitine: 28.21 / 19.93; propionylcarnitine: 3.17 / 4.61
SPME-LC-MS, median concentration / IQR, µg ml⁻¹, TERT alteration 1 α-Aminoadipic acid: 19.92 / 39.52; phenylalanine: 29.93 / 14.71; cystathionine: 78.26 / 323.01; acetylcarnitine: 25.13 / 31.64; propionylcarnitine: 1.48 / 1.08